CRISPR Interference–Potential Application in Retinal Disease

The treatment of dominantly inherited retinal diseases requires silencing of the pathogenic allele. RNA interference to suppress gene expression suffers from wide-spread off-target effects, while CRISPR-mediated gene disruption creates permanent changes in the genome. CRISPR interference uses a cata...

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Detalles Bibliográficos
Autores principales: Peddle, Caroline F., Fry, Lewis E., McClements, Michelle E., MacLaren, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177328/
https://www.ncbi.nlm.nih.gov/pubmed/32230903
http://dx.doi.org/10.3390/ijms21072329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177328/
https://www.ncbi.nlm.nih.gov/pubmed/32230903
http://dx.doi.org/10.3390/ijms21072329

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