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Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy

The T cells are key players of the response to checkpoint blockade immunotherapy (CBI) and monitoring the strength and specificity of antitumor T-cell reactivity remains a crucial but elusive component of precision immunotherapy. The entire assembly of T-cell receptor (TCR) sequences accounts for an...

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Autores principales: Aversa, Ilenia, Malanga, Donatella, Fiume, Giuseppe, Palmieri, Camillo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177412/
https://www.ncbi.nlm.nih.gov/pubmed/32235561
http://dx.doi.org/10.3390/ijms21072378
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author Aversa, Ilenia
Malanga, Donatella
Fiume, Giuseppe
Palmieri, Camillo
author_facet Aversa, Ilenia
Malanga, Donatella
Fiume, Giuseppe
Palmieri, Camillo
author_sort Aversa, Ilenia
collection PubMed
description The T cells are key players of the response to checkpoint blockade immunotherapy (CBI) and monitoring the strength and specificity of antitumor T-cell reactivity remains a crucial but elusive component of precision immunotherapy. The entire assembly of T-cell receptor (TCR) sequences accounts for antigen specificity and strength of the T-cell immune response. The TCR repertoire hence represents a “footprint” of the conditions faced by T cells that dynamically evolves according to the challenges that arise for the immune system, such as tumor neo-antigenic load. Hence, TCR repertoire analysis is becoming increasingly important to comprehensively understand the nature of a successful antitumor T-cell response, and to improve the success and safety of current CBI.
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spelling pubmed-71774122020-04-28 Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy Aversa, Ilenia Malanga, Donatella Fiume, Giuseppe Palmieri, Camillo Int J Mol Sci Review The T cells are key players of the response to checkpoint blockade immunotherapy (CBI) and monitoring the strength and specificity of antitumor T-cell reactivity remains a crucial but elusive component of precision immunotherapy. The entire assembly of T-cell receptor (TCR) sequences accounts for antigen specificity and strength of the T-cell immune response. The TCR repertoire hence represents a “footprint” of the conditions faced by T cells that dynamically evolves according to the challenges that arise for the immune system, such as tumor neo-antigenic load. Hence, TCR repertoire analysis is becoming increasingly important to comprehensively understand the nature of a successful antitumor T-cell response, and to improve the success and safety of current CBI. MDPI 2020-03-30 /pmc/articles/PMC7177412/ /pubmed/32235561 http://dx.doi.org/10.3390/ijms21072378 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Aversa, Ilenia
Malanga, Donatella
Fiume, Giuseppe
Palmieri, Camillo
Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy
title Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy
title_full Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy
title_fullStr Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy
title_full_unstemmed Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy
title_short Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy
title_sort molecular t-cell repertoire analysis as source of prognostic and predictive biomarkers for checkpoint blockade immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177412/
https://www.ncbi.nlm.nih.gov/pubmed/32235561
http://dx.doi.org/10.3390/ijms21072378
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