Trophectoderm-Specific Knockdown of LIN28 Decreases Expression of Genes Necessary for Cell Proliferation and Reduces Elongation of Sheep Conceptus

LIN28 inhibits let-7 miRNA maturation which prevents cell differentiation and promotes proliferation. We hypothesized that the LIN28-let-7 axis regulates proliferation-associated genes in sheep trophectoderm in vivo. Day 9-hatched sheep blastocysts were incubated with lentiviral particles to deliver...

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Detalles Bibliográficos
Autores principales: Ali, Asghar, Stenglein, Mark D., Spencer, Thomas E., Bouma, Gerrit J., Anthony, Russell V., Winger, Quinton A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177537/
https://www.ncbi.nlm.nih.gov/pubmed/32268593
http://dx.doi.org/10.3390/ijms21072549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177537/
https://www.ncbi.nlm.nih.gov/pubmed/32268593
http://dx.doi.org/10.3390/ijms21072549

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