Effective Cellular Transport of Ortho-Halogenated Sulfonamide Derivatives of Metformin Is Related to Improved Antiproliferative Activity and Apoptosis Induction in MCF-7 Cells

Metformin is a substrate for plasma membrane monoamine transporters (PMAT) and organic cation transporters (OCTs); therefore, the expression of these transporters and interactions between them may affect the uptake of metformin into tumor cells and its anticancer efficacy. The aim of this study was...

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Detalles Bibliográficos
Autores principales: Markowicz-Piasecka, Magdalena, Komeil, Ibrahim, Huttunen, Johanna, Sikora, Joanna, Huttunen, Kristiina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177633/
https://www.ncbi.nlm.nih.gov/pubmed/32235654
http://dx.doi.org/10.3390/ijms21072389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177633/
https://www.ncbi.nlm.nih.gov/pubmed/32235654
http://dx.doi.org/10.3390/ijms21072389

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