Karyopherin α-2 Mediates MDC1 Nuclear Import through a Functional Nuclear Localization Signal in the tBRCT Domain of MDC1

Mediator of DNA damage checkpoint protein 1 (MDC1) plays a vital role in DNA damage response (DDR) by coordinating the repair of double strand breaks (DSBs). Here, we identified a novel interaction between MDC1 and karyopherin α-2 (KPNA2), a nucleocytoplasmic transport adaptor, and showed that KPNA2...

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Detalles Bibliográficos
Autores principales: Radhakrishnan, Kamalakannan, Park, Seon-Joo, Kim, Seok Won, Hariharasudhan, Gurusamy, Jeong, Seo-Yeon, Chang, In Youb, Lee, Jung-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177644/
https://www.ncbi.nlm.nih.gov/pubmed/32290222
http://dx.doi.org/10.3390/ijms21072650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177644/
https://www.ncbi.nlm.nih.gov/pubmed/32290222
http://dx.doi.org/10.3390/ijms21072650

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