Aryl-4,5-dihydro-1H-pyrazole-1-carboxamide Derivatives Bearing a Sulfonamide Moiety Show Single-digit Nanomolar-to-Subnanomolar Inhibition Constants against the Tumor-associated Human Carbonic Anhydrases IX and XII

A series of new 3-phenyl-5-aryl-N-(4-sulfamoylphenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide derivatives was designed here, synthesized, and studied for carbonic anhydrase (CAs, EC 4.2.1.1) inhibitory activity against the human (h) isozymes I, II, and VII (cytosolic, off-target isoforms), and IX and...

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Detalles Bibliográficos
Autores principales: Hargunani, Priya, Tadge, Nikhil, Ceruso, Mariangela, Leitans, Janis, Kazaks, Andris, Tars, Kaspars, Gratteri, Paola, Supuran, Claudiu T., Nocentini, Alessio, Toraskar, Mrunmayee P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177888/
https://www.ncbi.nlm.nih.gov/pubmed/32283813
http://dx.doi.org/10.3390/ijms21072621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177888/
https://www.ncbi.nlm.nih.gov/pubmed/32283813
http://dx.doi.org/10.3390/ijms21072621

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