Generation of An Endogenous FGFR2–BICC1 Gene Fusion/58 Megabase Inversion Using Single-Plasmid CRISPR/Cas9 Editing in Biliary Cells

Fibroblast growth factor receptor 2 (FGFR2) gene fusions are bona fide oncogenic drivers in 10–15% of intrahepatic cholangiocarcinoma (CCA), yet currently there are no cell lines publically available to study endogenous FGFR2 gene fusions. The ability of clustered regularly interspaced short palindr...

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Detalles Bibliográficos
Autores principales: Reicher, Andreas, Harris, Antoneicka L, Prinz, Felix, Kiesslich, Tobias, Wei, Miaoyan, Öllinger, Rupert, Rad, Roland, Pichler, Martin, Kwong, Lawrence N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178239/
https://www.ncbi.nlm.nih.gov/pubmed/32252259
http://dx.doi.org/10.3390/ijms21072460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178239/
https://www.ncbi.nlm.nih.gov/pubmed/32252259
http://dx.doi.org/10.3390/ijms21072460

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