Generation of An Endogenous FGFR2–BICC1 Gene Fusion/58 Megabase Inversion Using Single-Plasmid CRISPR/Cas9 Editing in Biliary Cells

Fibroblast growth factor receptor 2 (FGFR2) gene fusions are bona fide oncogenic drivers in 10–15% of intrahepatic cholangiocarcinoma (CCA), yet currently there are no cell lines publically available to study endogenous FGFR2 gene fusions. The ability of clustered regularly interspaced short palindr...

Descripción completa

Detalles Bibliográficos
Autores principales: Reicher, Andreas, Harris, Antoneicka L, Prinz, Felix, Kiesslich, Tobias, Wei, Miaoyan, Öllinger, Rupert, Rad, Roland, Pichler, Martin, Kwong, Lawrence N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178239/
https://www.ncbi.nlm.nih.gov/pubmed/32252259
http://dx.doi.org/10.3390/ijms21072460

Ejemplares similares

Ejemplares similares