ERK Activation in CAR T Cells Is Amplified by CD28-Mediated Increase in CD3ζ Phosphorylation

Chimeric antigen receptors (CARs) are engineered receptors that mediate T cell activation. CARs are comprised of activating and co-stimulatory intracellular signaling domains derived from endogenous T cells that initiate signaling required for T cell activation, including ERK activation through the...

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Detalles Bibliográficos
Autores principales: Rohrs, Jennifer A., Siegler, Elizabeth L., Wang, Pin, Finley, Stacey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178546/
https://www.ncbi.nlm.nih.gov/pubmed/32325413
http://dx.doi.org/10.1016/j.isci.2020.101023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178546/
https://www.ncbi.nlm.nih.gov/pubmed/32325413
http://dx.doi.org/10.1016/j.isci.2020.101023

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