H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice

The host cell protease TMPRSS2 cleaves the influenza A virus (IAV) hemagglutinin (HA). Several reports have described resistance of Tmprss2(−/−) knock-out (KO) mice to IAV infection but IAV of the H2 subtype have not been examined yet. Here, we demonstrate that TMPRSS2 is able to cleave H2-HA in cel...

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Detalles Bibliográficos
Autores principales: Lambertz, Ruth Lydia Olga, Gerhauser, Ingo, Nehlmeier, Inga, Gärtner, Sabine, Winkler, Michael, Leist, Sarah Rebecca, Kollmus, Heike, Pöhlmann, Stefan, Schughart, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178614/
https://www.ncbi.nlm.nih.gov/pubmed/32321537
http://dx.doi.org/10.1186/s12985-020-01323-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178614/
https://www.ncbi.nlm.nih.gov/pubmed/32321537
http://dx.doi.org/10.1186/s12985-020-01323-z

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