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Targeting the 4-1BB costimulatory molecule through single chain antibodies promotes the human T-cell response
BACKGROUND: Adoptive T-cell therapy (ACT) using autologous tumor-reactive T lymphocytes has considerable potential for cancer immunotherapy. In ACT, T cells are isolated from cancer patients and then stimulated and expanded in vitro by cytokines and costimulatory molecules. 4-1BB is an important cos...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178758/ https://www.ncbi.nlm.nih.gov/pubmed/32336974 http://dx.doi.org/10.1186/s11658-020-00219-8 |