Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat

The spreading and accumulation of α-synuclein and dopaminergic neurodegeneration, two hallmarks of Parkinson’s disease (PD), have been faithfully reproduced in rodent brains by chronic, oral administration of β-sitosterol β-D-glucoside (BSSG). We investigated whether a single injection of BSSG (6 μg...

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Detalles Bibliográficos
Autores principales: Soto-Rojas, Luis O., Martínez-Dávila, Irma A., Luna-Herrera, Claudia, Gutierrez-Castillo, María E., Lopez-Salas, Francisco E., Gatica-Garcia, Bismark, Soto-Rodriguez, Guadalupe, Bringas Tobon, María Elena, Flores, Gonzalo, Padilla-Viveros, America, Bañuelos, Cecilia, Blanco-Alvarez, Víctor Manuel, Dávila-Ayala, José, Reyes-Corona, David, Garcés-Ramírez, Linda, Hidalgo-Alegria, Oriana, De La Cruz-lópez, Fidel, Martinez-Fong, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178762/
https://www.ncbi.nlm.nih.gov/pubmed/32321590
http://dx.doi.org/10.1186/s40478-020-00933-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178762/
https://www.ncbi.nlm.nih.gov/pubmed/32321590
http://dx.doi.org/10.1186/s40478-020-00933-6

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