Antiproliferative benzothiazoles incorporating a trimethoxyphenyl scaffold as novel colchicine site tubulin polymerisation inhibitors

Tubulin polymerisation inhibitors exhibited an important role in the treatment of patients with prostate cancer. Herein, we reported the medicinal chemistry efforts leading to a new series of benzothiazoles by a bioisosterism approach. Biological testing revealed that compound 12a could significantl...

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Detalles Bibliográficos
Autores principales: Fu, Dong-Jun, Liu, Si-Meng, Li, Fu-Hao, Yang, Jia-Jia, Li, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178834/
https://www.ncbi.nlm.nih.gov/pubmed/32299262
http://dx.doi.org/10.1080/14756366.2020.1753721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178834/
https://www.ncbi.nlm.nih.gov/pubmed/32299262
http://dx.doi.org/10.1080/14756366.2020.1753721

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