The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors

The clinically used antibiotic Furagin and its derivatives possess inhibitory activity on human (h) carbonic anhydrases (CA, EC 4.2.1.1), some of which are highly expressed in various tissues and malignancies (hCA IX/XII). Furagin exhibited good hCA IX and XII inhibition with K(I)s of 260 and 57 nM,...

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Detalles Bibliográficos
Autores principales: Pustenko, Aleksandrs, Nocentini, Alessio, Gratteri, Paola, Bonardi, Alessandro, Vozny, Igor, Žalubovskis, Raivis, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178874/
https://www.ncbi.nlm.nih.gov/pubmed/32297543
http://dx.doi.org/10.1080/14756366.2020.1752201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178874/
https://www.ncbi.nlm.nih.gov/pubmed/32297543
http://dx.doi.org/10.1080/14756366.2020.1752201

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