Mutations in Superoxide Dismutase 1 (Sod1) Linked to Familial Amyotrophic Lateral Sclerosis Can Disrupt High-Affinity Zinc-Binding Promoted by the Copper Chaperone for Sod1 (Ccs)

Zinc (II) ions (hereafter simplified as zinc) are important for the structural and functional activity of many proteins. For Cu, Zn superoxide dismutase (Sod1), zinc stabilizes the native structure of each Sod1 monomer, promotes homo-dimerization and plays an important role in activity by “softening...

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Detalles Bibliográficos
Autores principales: Boyd, Stefanie D., Ullrich, Morgan S., Calvo, Jenifer S., Behnia, Fatemeh, Meloni, Gabriele, Winkler, Duane D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179120/
https://www.ncbi.nlm.nih.gov/pubmed/32121118
http://dx.doi.org/10.3390/molecules25051086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179120/
https://www.ncbi.nlm.nih.gov/pubmed/32121118
http://dx.doi.org/10.3390/molecules25051086

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