Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy

The key problems of human immunodeficiency virus (HIV) therapy are the rapid emergence of drug-resistant mutant strains and significant cumulative drug toxicities. Therefore, there is an urgent demand for new anti-HIV agents with low toxicity and broad-spectrum antiviral potency. A series of bipheny...

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Detalles Bibliográficos
Autores principales: Lei, Yuan, Han, Sheng, Yang, Yang, Pannecouque, Christophe, De Clercq, Erik, Zhuang, Chunlin, Chen, Fen-Er
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179183/
https://www.ncbi.nlm.nih.gov/pubmed/32111013
http://dx.doi.org/10.3390/molecules25051050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179183/
https://www.ncbi.nlm.nih.gov/pubmed/32111013
http://dx.doi.org/10.3390/molecules25051050

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