Chiral Pyridine-3,5-bis- (L-phenylalaninyl-L-leucinyl) Schiff Base Peptides as Potential Anticancer Agents: Design, Synthesis, and Molecular Docking Studies Targeting Lactate Dehydrogenase-A

A series of branched tetrapeptide Schiff bases 3–6 were designed and synthesized from corresponding tetrapeptide hydrazide 2 as a starting material.In vitroevaluation of the synthesized compounds 4–6 against breast MCF-7 carcinoma cells identified their excellent anticancer potency, with IC(50) rang...

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Detalles Bibliográficos
Autores principales: Amr, Abd El-Galil E., Mageid, Randa E. Abdel, El-Naggar, Mohamed, M. Naglah, Ahmed, S. Nossier, Eman, Elsayed, Elsayed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179198/
https://www.ncbi.nlm.nih.gov/pubmed/32121469
http://dx.doi.org/10.3390/molecules25051096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179198/
https://www.ncbi.nlm.nih.gov/pubmed/32121469
http://dx.doi.org/10.3390/molecules25051096

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