Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities

7-Benzylidenenaltrexone (BNTX) and most of its derivatives showed in vitro antimalarial activities against chloroquine-resistant and -sensitive Plasmodium falciparum strains (K1 and FCR3, respectively). In addition, the time-dependent changes of the addition reactions of the BNTX derivatives with 1-...

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Detalles Bibliográficos
Autores principales: Kutsumura, Noriki, Koyama, Yasuaki, Saitoh, Tsuyoshi, Yamamoto, Naoshi, Nagumo, Yasuyuki, Miyata, Yoshiyuki, Hokari, Rei, Ishiyama, Aki, Iwatsuki, Masato, Otoguro, Kazuhiko, Ōmura, Satoshi, Nagase, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179212/
https://www.ncbi.nlm.nih.gov/pubmed/32131542
http://dx.doi.org/10.3390/molecules25051112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179212/
https://www.ncbi.nlm.nih.gov/pubmed/32131542
http://dx.doi.org/10.3390/molecules25051112

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