Identifying Novel ATX Inhibitors via Combinatory Virtual Screening Using Crystallography-Derived Pharmacophore Modelling, Docking Study, and QSAR Analysis

Autotaxin (ATX) is considered as an interesting drug target for the therapy of several diseases. The goal of the research was to detect new ATX inhibitors which have novel scaffolds by using virtual screening. First, based on two diverse receptor-ligand complexes, 14 pharmacophore models were develo...

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Detalles Bibliográficos
Autores principales: Ren, Ji-Xia, Zhang, Rui-Tao, Zhang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179221/
https://www.ncbi.nlm.nih.gov/pubmed/32131468
http://dx.doi.org/10.3390/molecules25051107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179221/
https://www.ncbi.nlm.nih.gov/pubmed/32131468
http://dx.doi.org/10.3390/molecules25051107

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