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Synthesis of Tetrabenazine and Its Derivatives, Pursuing Efficiency and Selectivity
Tetrabenazine is a US Food and Drug Administration (FDA)-approved drug that exhibits a dopamine depleting effect and is used for the treatment of chorea in Huntington’s disease. Mechanistically, tetrabenazine binds and inhibits vesicular monoamine transporter type 2, which is responsible for importi...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179236/ https://www.ncbi.nlm.nih.gov/pubmed/32151010 http://dx.doi.org/10.3390/molecules25051175 |