6′-β-Fluoro-Homoaristeromycin and 6′-Fluoro-Homoneplanocin A Are Potent Inhibitors of Chikungunya Virus Replication through Their Direct Effect on Viral Nonstructural Protein 1

Alphaviruses are arthropod-borne, positive-stranded RNA viruses capable of causing severe disease with high morbidity. Chikungunya virus (CHIKV) is an alphavirus that causes a febrile illness which can progress into chronic arthralgia. The current lack of vaccines and specific treatment for CHIKV in...

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Detalles Bibliográficos
Autores principales: Kovacikova, Kristina, Morren, Bas M., Tas, Ali, Albulescu, Irina C., van Rijswijk, Robin, Jarhad, Dnyandev B., Shin, Young Sup, Jang, Min Hwan, Kim, Gyudong, Lee, Hyuk Woo, Jeong, Lak Shin, Snijder, Eric J., van Hemert, Martijn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179274/
https://www.ncbi.nlm.nih.gov/pubmed/31964798
http://dx.doi.org/10.1128/AAC.02532-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179274/
https://www.ncbi.nlm.nih.gov/pubmed/31964798
http://dx.doi.org/10.1128/AAC.02532-19

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