TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against Mycobacterium abscessus

Lung disease caused by Mycobacterium abscessus is very difficult to cure, and treatment failure rates are high. The antituberculosis drug bedaquiline (BDQ) is used as salvage therapy against this dreadful disease. However, BDQ is highly lipophilic, displays a long terminal half-life, and presents a...

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Detalles Bibliográficos
Autores principales: Sarathy, Jickky Palmae, Ganapathy, Uday S., Zimmerman, Matthew D., Dartois, Véronique, Gengenbacher, Martin, Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179298/
https://www.ncbi.nlm.nih.gov/pubmed/31964791
http://dx.doi.org/10.1128/AAC.02404-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179298/
https://www.ncbi.nlm.nih.gov/pubmed/31964791
http://dx.doi.org/10.1128/AAC.02404-19

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