Lead Optimization of Dehydroemetine for Repositioned Use in Malaria

Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel antimalarial treatments. The antiamoebic compound emetine dihydrochloride has been identified as a potent in vitro inhibitor of the multidrug-resistant strain K1 of Plasmodium falciparum (50...

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Detalles Bibliográficos
Autores principales: Panwar, Priyanka, Burusco, Kepa K., Abubaker, Muna, Matthews, Holly, Gutnov, Andrey, Fernández-Álvaro, Elena, Bryce, Richard A., Wilkinson, James, Nirmalan, Niroshini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179302/
https://www.ncbi.nlm.nih.gov/pubmed/31964796
http://dx.doi.org/10.1128/AAC.01444-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179302/
https://www.ncbi.nlm.nih.gov/pubmed/31964796
http://dx.doi.org/10.1128/AAC.01444-19

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