Synthesis and Biological Evaluation of a Novel C8-Pyrrolobenzodiazepine (PBD) Adenosine Conjugate. A Study on the Role of the PBD Ring in the Biological Activity of PBD-Conjugates

Here we sought to evaluate the contribution of the PBD unit to the biological activity of PBD-conjugates and, to this end, an adenosine nucleoside was attached to the PBD A-ring C8 position. A convergent approach was successfully adopted for the synthesis of a novel C8-linked pyrrolo(2,1-c)(1,4)benz...

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Detalles Bibliográficos
Autores principales: Ferguson, Lindsay, Bhakta, Sanjib, Fox, Keith R., Wells, Geoff, Brucoli, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179398/
https://www.ncbi.nlm.nih.gov/pubmed/32164166
http://dx.doi.org/10.3390/molecules25051243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179398/
https://www.ncbi.nlm.nih.gov/pubmed/32164166
http://dx.doi.org/10.3390/molecules25051243

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