Abacavir Exposure in Children Cotreated for Tuberculosis with Rifampin and Superboosted Lopinavir-Ritonavir

In children requiring lopinavir coformulated with ritonavir in a 4:1 ratio (lopinavir-ritonavir-4:1) and rifampin, adding ritonavir to achieve a 4:4 ratio with lopinavir (LPV/r-4:4) overcomes the drug-drug interaction. Possible drug-drug interactions within this regimen may affect abacavir concentra...

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Detalles Bibliográficos
Autores principales: Rabie, Helena, Tikiso, Tjokosela, Lee, Janice, Fairlie, Lee, Strehlau, Renate, Bobat, Raziya, Liberty, Afaaf, McIlleron, Helen, Andrieux-Meyer, Isabelle, Cotton, Mark, Lallemant, Marc, Denti, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179606/
https://www.ncbi.nlm.nih.gov/pubmed/32071055
http://dx.doi.org/10.1128/AAC.01923-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179606/
https://www.ncbi.nlm.nih.gov/pubmed/32071055
http://dx.doi.org/10.1128/AAC.01923-19

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