Enhanced Efflux Pump Expression in Candida Mutants Results in Decreased Manogepix Susceptibility

Manogepix is a broad-spectrum antifungal agent that inhibits glycosylphosphatidylinositol (GPI) anchor biosynthesis. Using whole-genome sequencing, we characterized two efflux-mediated mechanisms in the fungal pathogens Candida albicans and Candida parapsilosis that resulted in decreased manogepix s...

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Detalles Bibliográficos
Autores principales: Liston, Sean D., Whitesell, Luke, Kapoor, Mili, Shaw, Karen Joy, Cowen, Leah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179633/
https://www.ncbi.nlm.nih.gov/pubmed/32179530
http://dx.doi.org/10.1128/AAC.00261-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179633/
https://www.ncbi.nlm.nih.gov/pubmed/32179530
http://dx.doi.org/10.1128/AAC.00261-20

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