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Enhanced Efflux Pump Expression in Candida Mutants Results in Decreased Manogepix Susceptibility

Manogepix is a broad-spectrum antifungal agent that inhibits glycosylphosphatidylinositol (GPI) anchor biosynthesis. Using whole-genome sequencing, we characterized two efflux-mediated mechanisms in the fungal pathogens Candida albicans and Candida parapsilosis that resulted in decreased manogepix s...

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Detalles Bibliográficos
Autores principales:	Liston, Sean D., Whitesell, Luke, Kapoor, Mili, Shaw, Karen Joy, Cowen, Leah E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179633/ https://www.ncbi.nlm.nih.gov/pubmed/32179530 http://dx.doi.org/10.1128/AAC.00261-20

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