Drug Effect of Clofazimine on Persisters Explains an Unexpected Increase in Bacterial Load in Patients

Antituberculosis (anti-TB) drug development is dependent on informative trials to secure the development of new antibiotics and combination regimens. Clofazimine (CLO) and pyrazinamide (PZA) are important components of recommended standard multidrug treatments of TB. Paradoxically, in a phase IIa tr...

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Detalles Bibliográficos
Autores principales: Faraj, Alan, Svensson, Robin J., Diacon, Andreas H., Simonsson, Ulrika S. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179644/
https://www.ncbi.nlm.nih.gov/pubmed/32122887
http://dx.doi.org/10.1128/AAC.01905-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179644/
https://www.ncbi.nlm.nih.gov/pubmed/32122887
http://dx.doi.org/10.1128/AAC.01905-19

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