Safety and Pharmacokinetic Characterization of Nacubactam, a Novel β-Lactamase Inhibitor, Alone and in Combination with Meropenem, in Healthy Volunteers

Nacubactam is a novel β-lactamase inhibitor with dual mechanisms of action as an inhibitor of serine β-lactamases (classes A and C and some class D) and an inhibitor of penicillin binding protein 2 in Enterobacteriaceae. The safety, tolerability, and pharmacokinetics of intravenous nacubactam were e...

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Detalles Bibliográficos
Autores principales: Mallalieu, Navita L., Winter, Erica, Fettner, Scott, Patel, Katie, Zwanziger, Elke, Attley, Gemma, Rodriguez, Ignacio, Kano, Akiko, Salama, Sameeh M., Bentley, Darren, Geretti, Anna Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179653/
https://www.ncbi.nlm.nih.gov/pubmed/32041717
http://dx.doi.org/10.1128/AAC.02229-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179653/
https://www.ncbi.nlm.nih.gov/pubmed/32041717
http://dx.doi.org/10.1128/AAC.02229-19

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