FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism

Silencing of FMR1 and loss of its gene product, FMRP, results in fragile X syndrome (FXS). FMRP binds brain mRNAs and inhibits polypeptide elongation. Using ribosome profiling of the hippocampus, we find that ribosome footprint levels in Fmr1-deficient tissue mostly reflect changes in RNA abundance....

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Detalles Bibliográficos
Autores principales: Shah, Sneha, Molinaro, Gemma, Liu, Botao, Wang, Ruijia, Huber, Kimberly M., Richter, Joel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179797/
https://www.ncbi.nlm.nih.gov/pubmed/32234480
http://dx.doi.org/10.1016/j.celrep.2020.02.076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179797/
https://www.ncbi.nlm.nih.gov/pubmed/32234480
http://dx.doi.org/10.1016/j.celrep.2020.02.076

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