Associations among smoking, MGMT hypermethylation, TP53-mutations, and relapse in head and neck squamous cell carcinoma

BACKGROUND: Epigenetic silencing of the O(6)-methylguanine-DNA methyltransferase (MGMT) DNA repair enzyme via promoter hypermethylation (hmMGMT) may increase mutations in the TP53 oncosuppressor gene and contribute to carcinogenesis. The effects of smoking, which is a risk factor for head and neck s...

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Detalles Bibliográficos
Autores principales: Matsuda, Shinichi, Mafune, Aki, Kohda, Nagisa, Hama, Takanori, Urashima, Mitsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179834/
https://www.ncbi.nlm.nih.gov/pubmed/32324779
http://dx.doi.org/10.1371/journal.pone.0231932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179834/
https://www.ncbi.nlm.nih.gov/pubmed/32324779
http://dx.doi.org/10.1371/journal.pone.0231932

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