The Aza-Analogous Benzo[c]phenanthridine P8-D6 Acts as a Dual Topoisomerase I and II Poison, thus Exhibiting Potent Genotoxic Properties

The benzo[c]phenanthridine P8-D6 was recently found to suppress the catalytic activity of both human topoisomerase (Topo) I and II. Concomitantly, potent cytotoxic activity was observed in different human tumor cell lines, raising questions about the underlying mechanisms in vitro. In the present st...

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Detalles Bibliográficos
Autores principales: Aichinger, Georg, Lichtenberger, Falk-Bach, Steinhauer, Tamara N., Flörkemeier, Inken, Del Favero, Giorgia, Clement, Bernd, Marko, Doris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180443/
https://www.ncbi.nlm.nih.gov/pubmed/32230817
http://dx.doi.org/10.3390/molecules25071524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180443/
https://www.ncbi.nlm.nih.gov/pubmed/32230817
http://dx.doi.org/10.3390/molecules25071524

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