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Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold
Natural oligonucleotides have many rotatable single bonds, and thus their structures are inherently flexible. Structural flexibility leads to an entropic loss when unwound oligonucleotides form a duplex with single-stranded DNA or RNA. An effective approach to reduce such entropic loss in the duplex...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180610/ https://www.ncbi.nlm.nih.gov/pubmed/32283778 http://dx.doi.org/10.3390/molecules25071732 |