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Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold

Natural oligonucleotides have many rotatable single bonds, and thus their structures are inherently flexible. Structural flexibility leads to an entropic loss when unwound oligonucleotides form a duplex with single-stranded DNA or RNA. An effective approach to reduce such entropic loss in the duplex...

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Detalles Bibliográficos
Autores principales:	Komine, Hibiki, Mori, Shohei, Morihiro, Kunihiko, Ishida, Kenta, Okuda, Takumi, Kasahara, Yuuya, Aoyama, Hiroshi, Yamaguchi, Takao, Obika, Satoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180610/ https://www.ncbi.nlm.nih.gov/pubmed/32283778 http://dx.doi.org/10.3390/molecules25071732

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