Design, Synthesis and Characterization of a New Series of Fluorescent Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulators

In recent years, new drug discovery approaches based on novel pharmacological concepts have emerged. Allosteric modulators, for example, target receptors at sites other than the orthosteric binding sites and can modulate agonist-mediated activation. Interestingly, allosteric regulation may allow a f...

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Detalles Bibliográficos
Autores principales: Fernández-Dueñas, Víctor, Qian, Mingcheng, Argerich, Josep, Amaral, Carolina, Risseeuw, Martijn D.P., Van Calenbergh, Serge, Ciruela, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180738/
https://www.ncbi.nlm.nih.gov/pubmed/32230915
http://dx.doi.org/10.3390/molecules25071532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180738/
https://www.ncbi.nlm.nih.gov/pubmed/32230915
http://dx.doi.org/10.3390/molecules25071532

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