Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs

Scaffold hopping is a frequently-used strategy in the development of non-nucleoside reverse transcriptase inhibitors. Herein, CH(CN)-DAPYs were designed by hopping the cyano-methylene linker of our previous published CH(CN)-DABOs onto the etravirine (ETR). Eighteen CH(CN)-DAPYs were synthesized and...

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Detalles Bibliográficos
Autores principales: Li, Ting-Ting, Pannecouque, Christophe, De Clercq, Erik, Zhuang, Chun-Lin, Chen, Fen-Er
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180830/
https://www.ncbi.nlm.nih.gov/pubmed/32235557
http://dx.doi.org/10.3390/molecules25071581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180830/
https://www.ncbi.nlm.nih.gov/pubmed/32235557
http://dx.doi.org/10.3390/molecules25071581

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