Quantification of an Antibody-Conjugated Drug in Fat Plasma by an Affinity Capture LC-MS/MS Method for a Novel Prenyl Transferase-Mediated Site-Specific Antibody–Drug Conjugate

The novel prenyl transferase-mediated, site-specific, antibody–drug conjugate LCB14-0110 is comprised of a proprietary beta-glucuronide linker and a payload (Monomethyl auristatin F, MMAF, an inhibitor for tubulin polymerization) attached to human epidermal growth factor receptor 2 (HER2)-targeting...

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Detalles Bibliográficos
Autores principales: Lee, Byeong ill, Park, Min-Ho, Byeon, Jin-Ju, Shin, Seok-Ho, Choi, Jangmi, Park, Yuri, Park, Yun-Hee, Chae, Jeiwook, Shin, Young G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180925/
https://www.ncbi.nlm.nih.gov/pubmed/32225092
http://dx.doi.org/10.3390/molecules25071515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180925/
https://www.ncbi.nlm.nih.gov/pubmed/32225092
http://dx.doi.org/10.3390/molecules25071515

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