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Quantification of an Antibody-Conjugated Drug in Fat Plasma by an Affinity Capture LC-MS/MS Method for a Novel Prenyl Transferase-Mediated Site-Specific Antibody–Drug Conjugate

The novel prenyl transferase-mediated, site-specific, antibody–drug conjugate LCB14-0110 is comprised of a proprietary beta-glucuronide linker and a payload (Monomethyl auristatin F, MMAF, an inhibitor for tubulin polymerization) attached to human epidermal growth factor receptor 2 (HER2)-targeting...

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Detalles Bibliográficos
Autores principales:	Lee, Byeong ill, Park, Min-Ho, Byeon, Jin-Ju, Shin, Seok-Ho, Choi, Jangmi, Park, Yuri, Park, Yun-Hee, Chae, Jeiwook, Shin, Young G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180925/ https://www.ncbi.nlm.nih.gov/pubmed/32225092 http://dx.doi.org/10.3390/molecules25071515

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