Cargando…

A Unique Gene-Silencing Approach, Using an Intelligent RNA Expression Device (iRed), Results in Minimal Immune Stimulation When Given by Local Intrapleural Injection in Malignant Pleural Mesothelioma

Background: We have recently introduced an intelligent RNA expression device (iRed), comprising the minimum essential components needed to transcribe short hairpin RNA (shRNA) in cells. Use of iRed efficiently produced shRNA molecules after transfection into cells and alleviated the innate immune st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ando, Hidenori, Saito-Tarashima, Noriko, Lila, Amr S. Abu, Kinjo, Nozomi, Shimizu, Taro, Ishima, Yu, Minakawa, Noriaki, Ishida, Tatsuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181240/ https://www.ncbi.nlm.nih.gov/pubmed/32283709 http://dx.doi.org/10.3390/molecules25071725

Ejemplares similares

Gene Silencing Using 4′-thioDNA as an Artificial Template to Synthesize Short Hairpin RNA Without Inducing a Detectable Innate Immune Response
por: Tarashima, Noriko, et al.
Publicado: (2016)

Adjuvant Antitumor Immunity Contributes to the Overall Antitumor Effect of Pegylated Liposomal Doxorubicin (Doxil(®)) in C26 Tumor-Bearing Immunocompetent Mice
por: Takayama, Takuma, et al.
Publicado: (2020)

Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of liposomal oxaliplatin in mouse model
por: Shimizu, Taro, et al.
Publicado: (2017)

The novel functional nucleic acid iRed effectively regulates target genes following cytoplasmic delivery by faint electric treatment
por: Hasan, Mahadi, et al.
Publicado: (2016)

Intrapleural administration of interleukin 2 in pleural mesothelioma: a phase I-II study.
por: Goey, S. H., et al.
Publicado: (1995)

Immune responses following intrapleural administration of oncolytic SEPREHVIR in patients with malignant pleural mesothelioma
por: Learmonth, Kirsty, et al.
Publicado: (2015)

Doxorubicin Embedded into Nanofibrillated Bacterial Cellulose (NFBC) Produces a Promising Therapeutic Outcome for Peritoneally Metastatic Gastric Cancer in Mice Models via Intraperitoneal Direct Injection
por: Ando, Hidenori, et al.
Publicado: (2021)

Synthesis and Behavior of DNA Oligomers Containing the Ambiguous Z-Nucleobase 5-Aminoimidazole-4-carboxamide
por: Nogi, Yuhei, et al.
Publicado: (2023)

Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways
por: Emam, Sherif E., et al.
Publicado: (2018)

Intrapleural silicone granuloma mimicking pleural malignancy
por: Vo, Kiet, et al.
Publicado: (2021)

Intrapleural Tenecteplase for Complicated Parapneumonic Pleural Effusion
por: Kadhem, Husain, et al.
Publicado: (2021)

FTY720 Reduces Lipid Accumulation by Upregulating ABCA1 through Liver X Receptor and Sphingosine Kinase 2 Signaling in Macrophages
por: Tachibana, Koki, et al.
Publicado: (2022)

Analysis of the Effect of Radiotherapy on Malignant Pleural Mesothelioma when Given on Adjuvant or Palliative Basis
por: El HOSSIENY, Hesham A., et al.
Publicado: (2010)

Malignant pleural mesothelioma in situ
por: Ando, Kohei, et al.
Publicado: (2022)

Medical management of pleural infection: Why not saline intrapleural lavage?
por: Mismetti, Valentine, et al.
Publicado: (2022)

Intrapleural Adenoviral-mediated Endothelial Cell Protein C Receptor Gene Transfer Suppresses the Progression of Malignant Pleural Mesothelioma in a Mouse Model
por: Keshava, Shiva, et al.
Publicado: (2016)

A novel intraperitoneal therapy for gastric cancer with DFP‐10825, a unique RNAi therapeutic targeting thymidylate synthase, in a peritoneally disseminated xenograft model
por: Ando, Hidenori, et al.
Publicado: (2019)

Intrapleural Bortezomib for the Therapy of Myelomatous Pleural Effusion: A Case Report
por: Klanova, Magdalena, et al.
Publicado: (2012)

Simple intrapleural hyperthermia at thoracoscopic exploration to treat malignant pleural effusion
por: Moon, Youngkyu, et al.
Publicado: (2015)

The Intrapleural Bridge Connection is One of the Reasons for Unknown Localized Pleural Adhesion
por: Gu, Qihua, et al.
Publicado: (2021)

Correlative analysis from a phase I clinical trial of intrapleural administration of oncolytic vaccinia virus (Olvi-vec) in patients with malignant pleural mesothelioma
por: Chintala, Navin K., et al.
Publicado: (2023)

The Therapeutic Effect of Human Serum Albumin Dimer-Doxorubicin Complex against Human Pancreatic Tumors
por: Kinoshita, Ryo, et al.
Publicado: (2021)

Short-course modified regimen intrapleural alteplase and pulmozyme (DNase) in pleural infection
por: Faisal, M., et al.
Publicado: (2020)

Comparison of intrapleural use of urokinase and tissue plasminogen activator/DNAse in pleural infection
por: Bédat, Benoît, et al.
Publicado: (2019)

Can intrapleural alteplase treatment be an alternative to videothoracoscopic deloculation and decortication in pleural empyema?
por: Kermenli, Tayfun, et al.
Publicado: (2021)

Ambulatory Intrapleural Fibrinolytic Therapy in Highly Viscous Recurrent Malignant Pleural Effusion
por: Foo, Chuan Tai, et al.
Publicado: (2021)

Malignant pleural mesothelioma presenting as a spontaneous pneumothorax
por: Mitsui, Ai, et al.
Publicado: (2015)

Optimization of a Luciferase-Expressing Non-Invasive Intrapleural Model of Malignant Mesothelioma in Immunocompetent Mice
por: Digifico, Elisabeth, et al.
Publicado: (2020)

Malignant pleural mesothelioma
por: Rao, Sukhesh
Publicado: (2009)

Intrapleural Corticosteroid Injection in Eosinophilic Pleural Effusion Associated with Undifferentiated Connective Tissue Disease
por: Kim, Eunjung, et al.
Publicado: (2013)

Intrapleural targeted therapies (anti-VEGF and anti-EGFR) in the model of malignant pleural effusion
por: Acencio, Milena Marques Pagliarelli, et al.
Publicado: (2017)

An international survey on the use of intrapleural tissue plasminogen activator/DNase therapy for pleural infection
por: Lau, Estee P.M., et al.
Publicado: (2022)

Malignant pleural mesothelioma with resolution of pleural effusion
por: Nishida, Sayaka, et al.
Publicado: (2023)

Pleural Mesothelioma: Advances in Blood and Pleural Biomarkers
por: Sorino, Claudio, et al.
Publicado: (2023)

Ultrasound-guided intrapleural positioning of pleural catheters: influence on immediate lung expansion and pleurodesis in patients with recurrent malignant pleural effusion
por: de Araujo, Pedro Henrique Xavier Nabuco, et al.
Publicado: (2017)

Should Lung-Sparing Surgery Be the Standard Procedure for Malignant Pleural Mesothelioma?
por: Ichiki, Yoshinobu, et al.
Publicado: (2020)

A Case of Successful Intrapleural Chemotherapy with Cisplatin Plus Cytarabine for Intractable Malignant Pleural Effusion
por: Moon, Yong Wha, et al.
Publicado: (2007)

Intrapleural hemorrhage due to alteplase use in a 6-year-old boy with pleural effusion
por: Hendaus, Mohamed A, et al.
Publicado: (2013)

Cytoreductive surgery combined with hyperthermic intrapleural chemotherapy to treat thymoma or thymic carcinoma with pleural dissemination
por: Yu, Lei, et al.
Publicado: (2013)

Low dose intrapleural alteplase and pulmozyme (DNase) in two post-surgical patients with pleural sepsis
por: Faisal, M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_oaffbmt0f5b30rfvrufgs0lr4t