One-Pot Iridium Catalyzed C–H Borylation/Sonogashira Cross-Coupling: Access to Borylated Aryl Alkynes

Borylated aryl alkynes have been synthesized via one-pot iridium catalyzed C–H borylation (CHB)/Sonogashira cross-coupling of aryl bromides. Direct borylation of aryl alkynes encountered problems related to the reactivity of the alkyne under CHB conditions. However, tolerance of aryl bromides to CHB...

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Autores principales: Chotana, Ghayoor A., Montero Bastidas, Jose R., Miller, Susanne L., Smith, Milton R., Maleczka, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181282/
https://www.ncbi.nlm.nih.gov/pubmed/32290238
http://dx.doi.org/10.3390/molecules25071754
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author Chotana, Ghayoor A.
Montero Bastidas, Jose R.
Miller, Susanne L.
Smith, Milton R.
Maleczka, Robert E.
author_facet Chotana, Ghayoor A.
Montero Bastidas, Jose R.
Miller, Susanne L.
Smith, Milton R.
Maleczka, Robert E.
author_sort Chotana, Ghayoor A.
collection PubMed
description Borylated aryl alkynes have been synthesized via one-pot iridium catalyzed C–H borylation (CHB)/Sonogashira cross-coupling of aryl bromides. Direct borylation of aryl alkynes encountered problems related to the reactivity of the alkyne under CHB conditions. However, tolerance of aryl bromides to CHB made possible a subsequent Sonogashira cross-coupling to access the desired borylated aryl alkynes.
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spelling pubmed-71812822020-04-28 One-Pot Iridium Catalyzed C–H Borylation/Sonogashira Cross-Coupling: Access to Borylated Aryl Alkynes Chotana, Ghayoor A. Montero Bastidas, Jose R. Miller, Susanne L. Smith, Milton R. Maleczka, Robert E. Molecules Article Borylated aryl alkynes have been synthesized via one-pot iridium catalyzed C–H borylation (CHB)/Sonogashira cross-coupling of aryl bromides. Direct borylation of aryl alkynes encountered problems related to the reactivity of the alkyne under CHB conditions. However, tolerance of aryl bromides to CHB made possible a subsequent Sonogashira cross-coupling to access the desired borylated aryl alkynes. MDPI 2020-04-10 /pmc/articles/PMC7181282/ /pubmed/32290238 http://dx.doi.org/10.3390/molecules25071754 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chotana, Ghayoor A.
Montero Bastidas, Jose R.
Miller, Susanne L.
Smith, Milton R.
Maleczka, Robert E.
One-Pot Iridium Catalyzed C–H Borylation/Sonogashira Cross-Coupling: Access to Borylated Aryl Alkynes
title One-Pot Iridium Catalyzed C–H Borylation/Sonogashira Cross-Coupling: Access to Borylated Aryl Alkynes
title_full One-Pot Iridium Catalyzed C–H Borylation/Sonogashira Cross-Coupling: Access to Borylated Aryl Alkynes
title_fullStr One-Pot Iridium Catalyzed C–H Borylation/Sonogashira Cross-Coupling: Access to Borylated Aryl Alkynes
title_full_unstemmed One-Pot Iridium Catalyzed C–H Borylation/Sonogashira Cross-Coupling: Access to Borylated Aryl Alkynes
title_short One-Pot Iridium Catalyzed C–H Borylation/Sonogashira Cross-Coupling: Access to Borylated Aryl Alkynes
title_sort one-pot iridium catalyzed c–h borylation/sonogashira cross-coupling: access to borylated aryl alkynes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181282/
https://www.ncbi.nlm.nih.gov/pubmed/32290238
http://dx.doi.org/10.3390/molecules25071754
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