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Improvement of sabinene tolerance of Escherichia coli using adaptive laboratory evolution and omics technologies

BACKGROUND: Biosynthesis of sabinene, a bicyclic monoterpene, has been accomplished in engineered microorganisms by introducing heterologous pathways and using renewable sugar as a carbon source. However, the efficiency and titers of this method are limited by the low host tolerance to sabinene (in...

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Detalles Bibliográficos
Autores principales: Wu, Tong, Liu, Jinfeng, Li, Meijie, Zhang, Ge, Liu, Lijuan, Li, Xing, Men, Xiao, Xian, Mo, Zhang, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181518/
https://www.ncbi.nlm.nih.gov/pubmed/32346395
http://dx.doi.org/10.1186/s13068-020-01715-x