Direct-acting antiviral treatment downregulates immune checkpoint inhibitor expression in patients with chronic hepatitis C

Chronic hepatitis C (CHC) infection is associated with increased TIM-3, PD-1 immune checkpoint receptors expression that inhibits adaptive T cells and increases NK cell cytotoxicity against T helper cells, both resulting T cell exhaustion. Elimination of the virus with direct-acting antivirals (DAAs...

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Detalles Bibliográficos
Autores principales: Szereday, Laszlo, Meggyes, Matyas, Berki, Timea, Miseta, Attila, Farkas, Nelli, Gervain, Judit, Par, Alajos, Par, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181552/
https://www.ncbi.nlm.nih.gov/pubmed/32108916
http://dx.doi.org/10.1007/s10238-020-00618-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181552/
https://www.ncbi.nlm.nih.gov/pubmed/32108916
http://dx.doi.org/10.1007/s10238-020-00618-3

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