Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles

Up-regulation of utrophin in muscles represents a promising therapeutic strategy for the treatment of Duchenne Muscular Dystrophy. We previously demonstrated that eEF1A2 associates with the 5’UTR of utrophin A to promote IRES-dependent translation. Here, we examine whether eEF1A2 directly regulates...

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Detalles Bibliográficos
Autores principales: Péladeau, Christine, Adam, Nadine, Bronicki, Lucas M., Coriati, Adèle, Thabet, Mohamed, Al-Rewashdy, Hasanen, Vanstone, Jason, Mears, Alan, Renaud, Jean-Marc, Holcik, Martin, Jasmin, Bernard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181625/
https://www.ncbi.nlm.nih.gov/pubmed/32332749
http://dx.doi.org/10.1038/s41467-020-15971-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181625/
https://www.ncbi.nlm.nih.gov/pubmed/32332749
http://dx.doi.org/10.1038/s41467-020-15971-w

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