Escape mutations circumvent a tradeoff between resistance to a beta-lactam and resistance to a beta-lactamase inhibitor

Beta-lactamase inhibitors are increasingly used to counteract antibiotic resistance mediated by beta-lactamase enzymes. These inhibitors compete with the beta-lactam antibiotic for the same binding site on the beta-lactamase, thus generating an evolutionary tradeoff: mutations that increase the enzy...

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Detalles Bibliográficos
Autores principales: Russ, Dor, Glaser, Fabian, Shaer Tamar, Einat, Yelin, Idan, Baym, Michael, Kelsic, Eric D., Zampaloni, Claudia, Haldimann, Andreas, Kishony, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181632/
https://www.ncbi.nlm.nih.gov/pubmed/32332717
http://dx.doi.org/10.1038/s41467-020-15666-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181632/
https://www.ncbi.nlm.nih.gov/pubmed/32332717
http://dx.doi.org/10.1038/s41467-020-15666-2

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