Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

Gene rv3722c of Mycobacterium tuberculosis is essential for in vitro growth, and encodes a putative pyridoxal phosphate-binding protein of unknown function. Here we use metabolomic, genetic and structural approaches to show that Rv3722c is the primary aspartate aminotransferase of M. tuberculosis, a...

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Detalles Bibliográficos
Autores principales: Jansen, Robert S., Mandyoli, Lungelo, Hughes, Ryan, Wakabayashi, Shoko, Pinkham, Jessica T., Selbach, Bruna, Guinn, Kristine M., Rubin, Eric J., Sacchettini, James C., Rhee, Kyu Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181641/
https://www.ncbi.nlm.nih.gov/pubmed/32327655
http://dx.doi.org/10.1038/s41467-020-15876-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181641/
https://www.ncbi.nlm.nih.gov/pubmed/32327655
http://dx.doi.org/10.1038/s41467-020-15876-8

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