Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts

The mechanisms that underpin how insertions or deletions (indels) become fixed in DNA have primarily been ascribed to replication-related and/or double-strand break (DSB)-related processes. Here, we introduce a method to evaluate indels, orientating them relative to gene transcription. In so doing,...

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Detalles Bibliográficos
Autores principales: Georgakopoulos-Soares, Ilias, Koh, Gene, Momen, Sophie E., Jiricny, Josef, Hemberg, Martin, Nik-Zainal, Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181645/
https://www.ncbi.nlm.nih.gov/pubmed/32332764
http://dx.doi.org/10.1038/s41467-020-15901-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181645/
https://www.ncbi.nlm.nih.gov/pubmed/32332764
http://dx.doi.org/10.1038/s41467-020-15901-w

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