Novel metabolic role for BDNF in pancreatic β-cell insulin secretion

BDNF signaling in hypothalamic circuitries regulates mammalian food intake. However, whether BDNF exerts metabolic effects on peripheral organs is currently unknown. Here, we show that the BDNF receptor TrkB.T1 is expressed by pancreatic β-cells where it regulates insulin release. Mice lacking TrkB....

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Detalles Bibliográficos
Autores principales: Fulgenzi, Gianluca, Hong, Zhenyi, Tomassoni-Ardori, Francesco, Barella, Luiz F., Becker, Jodi, Barrick, Colleen, Swing, Deborah, Yanpallewar, Sudhirkumar, Croix, Brad St, Wess, Jürgen, Gavrilova, Oksana, Tessarollo, Lino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181656/
https://www.ncbi.nlm.nih.gov/pubmed/32327658
http://dx.doi.org/10.1038/s41467-020-15833-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181656/
https://www.ncbi.nlm.nih.gov/pubmed/32327658
http://dx.doi.org/10.1038/s41467-020-15833-5

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