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Elevated O-GlcNAcylation induces an antidepressant-like phenotype and decreased inhibitory transmission in medial prefrontal cortex

Depression is a devastating mental disorder affected by multiple factors that can have genetic, environmental, or metabolic causes. Although previous studies have reported an association of dysregulated glucose metabolism with depression, its underlying mechanism remains elusive at the molecular lev...

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Detalles Bibliográficos
Autores principales: Cho, Yoonjeong, Hwang, Hongik, Rahman, Md. Ataur, Chung, ChiHye, Rhim, Hyewhon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181662/
https://www.ncbi.nlm.nih.gov/pubmed/32332789
http://dx.doi.org/10.1038/s41598-020-63819-6