Neuroligin-1 is altered in the hippocampus of Alzheimer’s disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers

Synapse loss occurs early and correlates with cognitive decline in Alzheimer’s disease (AD). Synaptotoxicity is driven, at least in part, by amyloid-beta oligomers (Aβo), but the exact synaptic components targeted by Aβo remain to be identified. We here tested the hypotheses that the post-synaptic p...

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Detalles Bibliográficos
Autores principales: Dufort-Gervais, Julien, Provost, Chloé, Charbonneau, Laurence, Norris, Christopher M., Calon, Frédéric, Mongrain, Valérie, Brouillette, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181681/
https://www.ncbi.nlm.nih.gov/pubmed/32332783
http://dx.doi.org/10.1038/s41598-020-63255-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181681/
https://www.ncbi.nlm.nih.gov/pubmed/32332783
http://dx.doi.org/10.1038/s41598-020-63255-6

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