Statin as anti-cancer therapy in autochthonous T-lymphomas expressing stabilized gain-of-function mutant p53 proteins

An important component of missense mutant p53 gain-of-function (mutp53 GOF) activities is the ability of stabilized mutp53 proteins to upregulate the mevalonate pathway, providing a rationale for exploring the statin family of HMG-CoA reductase inhibitors as anticancer agents in mutp53 tumors. In th...

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Detalles Bibliográficos
Autores principales: Tutuska, Karis, Parrilla-Monge, Laura, Di Cesare, Erica, Nemajerova, Alice, Moll, Ute M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181693/
https://www.ncbi.nlm.nih.gov/pubmed/32332697
http://dx.doi.org/10.1038/s41419-020-2466-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181693/
https://www.ncbi.nlm.nih.gov/pubmed/32332697
http://dx.doi.org/10.1038/s41419-020-2466-4

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